![]() The second meta-analysis pooled six articles totaling over 6000 patients. 12 pooled 16 studies totaling over 7000 SSc patients and calculated a relative risk of 1.75 (95% CI = 1.41–2.18) for cancer compared to the general population. ![]() In 2013, three meta-analyses were published to synthesize findings from the multitude of observational cohort studies. Others, however, have been less consistently found, including breast and thyroid cancers. Historically, some cancer types have been a consistent finding, such as lung cancer (attributed at least in part to interstitial lung disease). Lung, non-Hodgkin’s lymphoma, hematopoieticĪ large number of tumor types have been observed to occur more frequently in SSc patients, including lung, liver, esophageal and oral cavity, thyroid, melanoma, non-melanoma skin, and hematologic among others. ![]() Male sex, first 12 months after diagnosis Lung, liver, hematologic, non-Hodgkin’s, leukemia, bladder, non-melanoma skin (men) Meta-analysis of population-based cohort studies Lung, oral cavity and pharynx, hematologic Research Group for the population-based cancer registrationĬatastrophic illness registry of the Taiwan National Health Insurance Research Data set Kitasato University Hospital scleroderma cohort (Japan) South West Cancer Intelligence Service Registry Lung, hematologic, immune-related cancers (including non-melanoma skin) Lung, stomach, esophagus, liver, pancreas Korean SSc patients evaluated at Kangnam St Mary’s Hospital Older age at scleroderma diagnosis, smoking, family history of cancer Limited scleroderma, black females (liver) Inpatient registry (whole country, Sweden) ![]() Inpatient registry (six counties, Sweden) Lung, breast, cervix, oral cavity, melanoma, prostate, testicle, uterus Ontario population data from 1985 to 1986 National Cancer Incidence Reporting System ![]() Scleroderma clinic at Wellesley Hospital (Canada) Third National Cancer Survey of 1969–1971 Pittsburgh cohort living in Pittsburgh metro area (US) ![]()
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